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Vetsulin Insulin U-40 for Dogs & Cats

by Merck

This item requires prescription approval.

Prescription medications are currently limited to CA residents. More states coming soon!!

Original price $70.99 - Original price $70.99
Original price
$70.99 - $70.99
Current price $70.99
Size: 10mL


Vetsulin is an injectable insulin suspension that reduces hyperglycemia (high blood sugar) in pets with diabetes.


  • The first FDA-approved insulin for use in dogs and cats with diabetes.
  • Controls glucose levels
  • Lessens signs of diabetes
  • Used for over 25 years worldwide

Consult with your veterinarian for proper dosage and course of treatment.



Owners should be advised to observe for signs of hypoglycemia (see Owner Information Sheet). Use of this product, even at established doses, has been associated with hypoglycemia. An animal with signs of hypoglycemia should be treated immediately. Glucose should be given orally or intravenously as dictated by clinical signs. Insulin should be temporarily withheld and, subsequently, the dosage should be adjusted, if indicated. Any change in insulin should be made cautiously and only under a veterinarian’s supervision. Changes in insulin strength, manufacturer, type, species (animal, human) or method of manufacture (rDNA versus animal-source insulin) may result in the need for a change in dosage.

Appropriate diagnostic tests should be performed to rule out endocrinopathies in pets that are difficult to regulate (e.g., hyperadrenocorticism in dogs and hyperthyroidism in cats).

Dogs and cats known to have a systemic allergy to pork or pork products should not be treated with Vetsulin. Vetsulin is contraindicated during periods of hypoglycemia.


Animals presenting with severe ketoacidosis, anorexia, lethargy, and/or vomiting should be stabilized with short-acting insulin and appropriate supportive therapy until their condition is stabilized. As with all insulin products, careful patient monitoring for hypoglycemia and hyperglycemia are essential to attain and maintain adequate glycemic control and prevent associated complications. Overdosage can result in profound hypoglycemia and death. Progestogens, certain endocrinopathies, and glucocorticoids can have an antagonistic effect on insulin activity. Intact bitches should be ovariohysterectomized.

Progestogen and glucocorticoid use should be avoided.


Food and Drug Interactions

In the US clinical effectiveness studies, dogs and cats received various medications while being treated with vetsulin® including antimicrobials, antivirals, antifungals, antihistamines, analgesics, anesthetics/tranquilizers, diuretics, bronchodilators, corticosteroids (cats), NSAIDs, thyroid hormone supplementation, hyperthyroid medication (methimazole), internal and external parasiticides, anti-emetics, dermatological topical treatments and oral supplements, ophthalmic preparations containing antimicrobials and antiinflammatories, and various vaccines. No medication interactions were reported. This drug was not studied in dogs receiving corticosteroids.

Human Warnings

For use in animals only. Keep out of the reach of children. Avoid contact with eyes. In case of contact, immediately flush eyes with copious amounts of water for 15 minutes. Accidental injection may cause clinical hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systemic allergic reaction in sensitized individuals.


Possible Side Effects

The most common insulin-related side effect is low blood sugar (hypoglycemia) with symptoms that include lethargy, staggering gait, seizure or coma. Contact your veterinarian immediately if your pet has a medical problem or side effect from Vetsulin therapy.


Contact your veterinarian if you believe your pet is experiencing side effects.


Product Administration


Product Form



Purified Porcine Insulin (35% Amorphous And 65% Crystalline) 40 IU, Zinc (As Chloride), Sodium Acetate Trihydrate, Sodium Chloride, Methylparaben


Store in an upright position under refrigeration at 36° - 46°F. Do not freeze. Protect from light. Use product within 42 days of the first puncture.

Prescribing Info/Brochures