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Simparica Trio Chewable Tablet for Dogs

by Zoetis

This item requires prescription approval.

Prescription medications are currently limited to CA residents. More states coming soon!!

Original price $159.99 - Original price $191.99
Original price
$159.99 - $191.99
Current price $159.99
Size: 2.8lbs-5.5lbs
Count: 6 Month

Simparica Trio is the first and only FDA-Approved Product of Its Kind Simparica Trio is a once-a-month chewable that protects your dog with three proven ingredients designed for defense. It’s available from your vet with a prescription


  • Protects dogs against heartworm disease, ticks & fleas, roundworms & hookworms.
  • FDA-approved to block infections that may cause Lyme disease by killing deer ticks.
  • Demonstrated safe for puppies as young as 8 weeks old, weighing at least 2.8 lbs.

Consult with your veterinarian for proper dosage and course of treatment.


Prior to administration of SIMPARICA TRIO, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. SIMPARICA TRIO is not effective against adult D. immitis


Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.

Food and Drug Interactions


Human Warnings

Not for use in humans. Keep this and all drugs out of reach of children.

Possible Side Effects

The most frequent reactions reported in the SIMPARICA TRIO group are Vomiting, Diarrhea, Lethargy, Anorexia, Polyuria, Hyperactivity, and Polydipsia.

Contact your veterinarian if you believe your pet is experiencing side effects.

Product Administration


Product Form

Chewable Tablet


Sarolaner, Moxidectin, and Pyrantel


Store at or below 30°C (86°F)



Prescribing Info/Brochures